AN elderly woman has died after a head-on crash on the Port River Expressway at Gillman that hospitalised three other people.
Emergency services were called to the three-car crash just after 7pm on Tuesday.
While the circumstances are unclear, two cars were pushed off the road, including a Nissan ute that appears to have been spun around by the force of the impact.
An extensively damaged Mazda hatchback was mounted on the central median strip of the road about 100m away from the other two vehicles.
A third car, a Mazda sedan, was also involved.
Debris, glass and vehicle fragments are strewn across the roadway for more than 100m.
The driver of the hatchback a 77-year-old woman from Osbourne, was taken to the RAH in a critical condition but later died from her injuries.
Her passenger, a 79-year-old woman from Glenside was also taken to the RAH with serious but not life-threatening injuries.
The driver of the Nissan received minor injuries and was taken to the Lyell McEwin Hospital.
The driver of the Mazda sedan was uninjured but also taken to the Lyell McEwin to be medically assessed. Neither of those cars had passengers.
The Expressway was closed completely to eastbound traffic on Tuesday night, while one lane was open to westbound traffic.
Police are asking motorists to avoid the area while major-crash investigators examine the scene.
Major Crash have been marking the location of skid marks and debris but were working in almost complete darkness on the gloomy stretch of road.
The woman’s death takes the state road toll to 54 compared with 47 for the same time last year.