The police have appealed for witnesses who saw the manner in which the cars were being driven before the incident between the Trecenydd roundabout and the Cedar Tree Roundabout.
The collision involved a silver Kia Sorento, a red Fiat 500, a blue Toyota Yaris and a blue Vauxhall Corsa.
The occupants of three of the cars were taken to hospital for treatment, and two of them have since been released.